Colchicine
Colchicine is a medication most commonly used to treat gout. It is a toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum (autumn crocus, Colchicum autumnale, also known as “meadow saffron”).
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Product Description
| N-[(7S)-1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide |
| Trade names | Colcrys |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a682711 |
| Pregnancy category |
AU: D US: C (Risk not ruled out) |
| Legal status |
AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: ℞-only |
| Routes of administration |
Oral |
| Bioavailability | 45% |
| Protein binding | 34-44% |
| Metabolism | Metabolism, partly by CYP3A4 |
| Biological half-life | 26.6-31.2 hours |
| Excretion | Faeces (65%) |
| CAS Number | 64-86-8 |
| ATC code | M04AC01 |
| PubChem | CID: 6167 |
| IUPHAR/BPS | 2367 |
| DrugBank | DB01394 |
| ChemSpider | 5933 |
| UNII | SML2Y3J35T |
| KEGG | D00570 |
| ChEBI | CHEBI:27882 |
| ChEMBL | CHEMBL107 |
| Formula | C22H25NO6 |
| Molecular mass | 399.437 |
| SMILES[show] | |
| InChI[show] | |
