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acetaminophen-dc-90

Acetaminophen Powder

Paracetamol, also known as acetaminophen or APAP, is a medication used to treat pain and fever.[9] It is typically used for mild to moderate pain.[9] Evidence of benefit in fever for children is poor.[10] It is often sold in combination with other ingredients such as in many cold medications.[9] In combination with opioid pain medication, paracetamol is used for more severe pain such as cancer pain and after surgery.[11] It is typically used either by mouth or rectally but is also available intravenously.[9][12] Effects last between two and four hours.[12]

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Product Description


N-(4-hydroxyphenyl)ethanamide
N-(4-hydroxyphenyl)acetamide

Pronunciation Paracetamol /ˌpærəˈsiːtəmɒl/ or /ˌpærəˈsɛtəmɒl/
Acetaminophen i/əˌsiːtəˈmɪnəfᵻn/
Trade names Tylenol, Panadol, others[1]
AHFS/Drugs.com monograph
MedlinePlus a681004
Licence data US FDA:link
Pregnancy
category

AU: A
US: C (Risk not ruled out)

Not tested but seems to be safe

Legal status

AU: Unscheduled
UK: General sales list (GSL, OTC)
US: OTC

Routes of
administration
Oral, rectal, intravenous

Bioavailability 63–89%[2]:73
Protein binding 10–25%[3]
Metabolism Predominantly in the liver[4]
Metabolites APAP gluc, APAP sulfate, NAPQI, APAP-GSH, APAP-cys[5]
Biological half-life 1–4 hours[4]
Excretion Urine (85–90%)[4]

CAS Number 103-90-2
ATC code N02BE01
PubChem CID: 1983
IUPHAR/BPS 5239
DrugBank DB00316
ChemSpider 1906
UNII 362O9ITL9D
KEGG D00217
ChEBI CHEBI:46195
ChEMBL CHEMBL112
PDB ligand ID TYL (PDBe, RCSB PDB)

Formula C8H9NO2
Molecular mass 151.163 g/mol
SMILES[show]

InChI[show]

Density 1.263 g/cm3
Melting point 169 °C (336 °F) [7][8]
Boiling point 420 °C (788 °F)
Solubility in water 12.78[6] mg/mL (20 °C)