Colistin (polymyxin E) is a polymyxin antibiotic produced by certain strains of Paenibacillus polymyxa var. colistinus. Colistin is a mixture of cyclic polypeptides colistin A and B. Colistin is effective against most Gram-negative bacilli and is used as a polypeptide antibiotic.
Starting at
N-(4-amino-1-(1-(4-amino-1-oxo-1-(3,12,23-tris(2-aminoethyl)- 20-(1-hydroxyethyl)-6,9-diisobutyl-2,5,8,11,14,19,22-heptaoxo- 1,4,7,10,13,18-hexaazacyclotricosan-15-ylamino)butan-2-ylamino)- 3-hydroxybutan-2-ylamino)-1-oxobutan-2-yl)-N,5-dimethylheptanamide |
Trade names | Coly-mycinm; Coly-monas(India) |
Pregnancy category |
C |
Legal status | PoM (UK), not available in US |
Routes of administration |
topical, oral, intravenous, inhaled |
Bioavailability | 0% |
Biological half-life | 5 hours |
CAS Number | 1264-72-8 |
ATC code | A07AA10 J01XB01 QJ51XB01 |
PubChem | CID: 5311054 |
DrugBank | DB00803 |
ChemSpider | 4470591 |
UNII | WP15DXU577 |
KEGG | D02138 |
ChEMBL | CHEMBL501505 |
Formula | C52H98N16O13 |
Molecular mass | 1155.4495 g/mol |
SMILES[show] | |
InChI[show] |