Loratadine is a second-generation[1] peripheral histamine H1-receptors blocker[2] used to treat allergies. In structure, it is closely related to tricyclic antidepressants, such as imipramine, and is distantly related to the atypical antipsychotic quetiapine.[3]
Starting at
Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate |
Trade names | Claritin |
AHFS/Drugs.com | monograph |
MedlinePlus | a697038 |
Pregnancy category |
AU: B1 US: B (No risk in non-human studies) |
Legal status |
CA : OTC UK : General sales list (GSL, OTC) US : OTC |
Routes of administration |
oral |
Bioavailability | almost 100% |
Protein binding | 97–99% |
Metabolism | Hepatic (CYP2D6- and 3A4-mediated) |
Biological half-life | 8 hours, active metabolite desloratadine 27 hours |
Excretion | 40% as conjugated metabolites into urine Similar amount into the feces |
CAS Number | 79794-75-5 |
ATC code | R06AX13 |
PubChem | CID: 3957 |
IUPHAR/BPS | 7216 |
DrugBank | DB00455 |
ChemSpider | 3820 |
UNII | 7AJO3BO7QN |
KEGG | D00364 |
ChEMBL | CHEMBL998 |