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Loratadine

Loratadine

Loratadine is a second-generation[1] peripheral histamine H1-receptors blocker[2] used to treat allergies. In structure, it is closely related to tricyclic antidepressants, such as imipramine, and is distantly related to the atypical antipsychotic quetiapine.[3]

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Product Description


Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate

Trade names Claritin
AHFS/Drugs.com monograph
MedlinePlus a697038
Pregnancy
category
AU: B1
US: B (No risk in non-human studies)
Legal status CA : OTC
UK : General sales list (GSL, OTC)
US : OTC
Routes of
administration
oral

Bioavailability almost 100%
Protein binding 97–99%
Metabolism Hepatic (CYP2D6- and 3A4-mediated)
Biological half-life 8 hours, active metabolite desloratadine 27 hours
Excretion 40% as conjugated metabolites into urine
Similar amount into the feces

CAS Number 79794-75-5
ATC code R06AX13
PubChem CID: 3957
IUPHAR/BPS 7216
DrugBank DB00455
ChemSpider 3820
UNII 7AJO3BO7QN
KEGG D00364
ChEMBL CHEMBL998

Formula C22H23ClN2O2 Molecular mass 382.88 g/mol SMILES[show] InChI[show]