Meclizine Hcl
Meclizine (INN,[1] or meclozine) is an antihistamine considered to be an antiemetic. It is sold under the brand names Bonine, Bonamine, Antivert, Postafen, Sea Legs, and Dramamine II (Less Drowsy Formulation). Emesafene is a combination of meclizine (1/3) and pyridoxine (2/3). In Canada, Antivert Tab (which is no longer available) was a combination of meclizine and nicotinic acid.[2]
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Product Description
| (RS)-1-[(4-chlorophenyl)(phenyl)methyl]-4-(3-methylbenzyl)piperazine |
| MedlinePlus | a682548 |
| Pregnancy category |
US: B (No risk in non-human studies) |
| Legal status |
AU: S4 (Prescription only) CA: OTC US: OTC |
| Routes of administration |
Oral, sublingual/buccal |
| Metabolism | hepatic |
| Biological half-life | 6 hours |
| CAS Number | 569-65-3 |
| ATC code | R06AE05 |
| PubChem | CID: 4034 |
| IUPHAR/BPS | 2757 |
| DrugBank | DB00737 |
| ChemSpider | 3894 |
| UNII | 3L5TQ84570 |
| ChEMBL | CHEMBL1623 |
| Formula | C25H27ClN2 |
| Molecular mass | 390.948 g/mol |
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| Boiling point | 230 °C (446 °F) |
