Nimesulide
Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old. It has a multifactorial mode of action and is characterized by a fast onset of action.
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Product Description
| N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide |
| AHFS/Drugs.com | International Drug Names |
| Legal status |
AU: S4 (Prescription only) Usually prescription only |
| Routes of administration |
Oral, rectal, topical |
| Protein binding | >97.5% |
| Metabolism | Hepatic |
| Biological half-life | 1.8–4.7h |
| Excretion | Renal (50%), fecal (29%) |
| CAS Number | 51803-78-2 |
| ATC code | M01AX17 M02AA26 |
| PubChem | CID: 4495 |
| IUPHAR/BPS | 7401 |
| DrugBank | DB04743 |
| ChemSpider | 4339 |
| UNII | V4TKW1454M |
| KEGG | D01049 |
| ChEBI | CHEBI:44445 |
| ChEMBL | CHEMBL56367 |
| Formula | C13H12N2O5S |
| Molecular mass | 308.311 g/mol |
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