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phenylephrine-hcl

Phenylephrine Hcl

Phenylephrine is a selective α1-adrenergic receptor agonist of the phenethylamine class used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure. Phenylephrine is marketed as an alternative for the decongestant pseudoephedrine, though clinical studies show phenylephrine to be no more effective than placebo.[1][2] Phenylephrine can also cause a decrease in heart rate through reflex bradycardia.[3]

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Product Description


(R)-3-[-1-hydroxy-2-(methylamino)ethyl]phenol

Pregnancy
category
US: C (Risk not ruled out)
Legal status UK: General sales list (GSL, OTC)
US: OTC
Routes of
administration
Oral, intranasal, ophthalmic, intravenous, intramuscular

Bioavailability 38% through GI tract
Protein binding 95%
Metabolism Hepatic (monoamine oxidase)
Biological half-life 2.1–3.4 h

CAS Number 59-42-7
61-76-7 (hydrochloride)
ATC code C01CA06 R01AA04, R01AB01 (combinations), R01BA03, S01FB01, S01GA05
PubChem CID: 6041
IUPHAR/BPS 485
DrugBank DB00388
ChemSpider 5818
UNII 1WS297W6MV
KEGG D08365
ChEBI CHEBI:8093
ChEMBL CHEMBL1215

Formula C9H13NO2
Molecular mass 167.205 g/mol

SMILES[show]

InChI[show]