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Ranitidine

Ranitidine , sold under the trade name Zantac among others, is a medication that decreases stomach acid production. It is commonly used in treatment of peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome. There is also tentative evidence of benefit for hives. It can be taken by mouth, by injection into a muscle, or into a vein.

Common side effects include headaches and pain or burning if given by injection. Serious side effects may include liver problems, a slow heart rate, pneumonia, and the potential of masking stomach cancer. It is also linked to an increased the risk of Clostridium difficile colitis. It is generally safe in pregnancy. Ranitidine is an H2 histamine receptor antagonist that works by blocking histamine and thus decreasing the amount of acid released by cells of the stomach.

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Product Description



N-(2-[(5-[(dimethylamino)methyl]furan-2-yl)methylthio]ethyl)-N’-methyl-2-nitroethene-1,1-diamine


Clinical data
Pronunciation /rəˈnɪtᵻdiːn/
Trade names Zantac, others
AHFS/Drugs.com monograph
MedlinePlus a601106
Licence data US FDA:link
Pregnancy category
  • AU: B1
  • US: B (No risk in non-human studies)
Legal status
  • AU: S2 (Pharmacy only)
  • UK: P/POM
  • US: OTC/RX
Routes of administration Oral, IV


Bioavailability 39 to 88%
Protein binding 15%
Metabolism Hepatic
Biological half-life 2–3 hours
Excretion 30–70% Renal


CAS Number 66357-35-5 
ATC code A02BA02 A02BA07 (ranitidine bismuth citrate)
PubChem CID: 3001055
IUPHAR/BPS 1234
DrugBank DB00863 
ChemSpider 4863
UNII 884KT10YB7 
KEGG D00422 
ChEBI CHEBI:8776 
ChEMBL CHEMBL1790041 
Synonyms Dimethyl [(5-{[(2-{[1-(methylamino)-2-nitroethenyl]amino}ethyl)sulfanyl]methyl}furan-2-yl)methyl]amine


Formula C13H22N4O3S
Molecular mass 314.4 g/mol

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