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tetracycline-hcl-product

Tetracycline Hcl

Tetracycline is an antibiotic used to treat a number of bacterial infections. It is commonly used to treat acne and rosacea. Historically it was important in reducing the number of deaths from cholera.

It is broad-spectrum and of the polyketide class. It is produced by the Streptomyces genus of Actinobacteria. It is a protein synthesis inhibitor.

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[1] Tetracycline is marketed under the brand names Sumycin, Tetracyn, Lymecycline, and Panmycin, among others. Actisite is a thread-like fiber formulation used in dental applications. It is also used to produce several semisynthetic derivatives, which together are known as the tetracycline antibiotics. The term “tetracycline” is also used to denote the four-ring system of this compound; “tetracyclines” are related substances that contain the same four-ring system.

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Product Description



Pronunciation /ˌtɛtrəˈsaɪkliːn/
Trade names Sumycin
AHFS/Drugs.com monograph
MedlinePlus a682098
Licence data US FDA:link
Pregnancy
category
  • AU: D
  • US: D (Evidence of risk)
Legal status
  • ℞ (Prescription only)
Routes of
administration
oral, topical (skin and eye), intramuscular, intravenous


Bioavailability 75%
Metabolism Not metabolised
Biological half-life 8-11 hours, 57-108 hours (kidney impairment)
Excretion Urine (>60%), feces


CAS Number 60-54-8  64-75-5 (hydrochloride)
ATC code A01AB13 D06AA04 J01AA07 S01AA09 S02AA08 S03AA02 QG01AA90 QG51AA02 QJ51AA07
PubChem CID: 643969
DrugBank DB00759 
ChemSpider 10257122 
UNII F8VB5M810T 
KEGG D00201 
ChEBI CHEBI:27902 
ChEMBL CHEMBL1440 


Formula C22H24N2O8
Molecular mass 444.435 g/mol

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