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orlistat

Orlistat

Orlistat (also known as tetrahydrolipstatin) is a drug designed to treat obesity. It is marketed as a prescription drug under the trade name Xenical by Roche in most countries, and is sold over-the-counter as Alli[2] by GlaxoSmithKline in the United Kingdom and the United States.[3] Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet.[4]

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Product Description


(S)-((S)-1-((2S,3S)-3-Hexyl-4-oxooxetan-2-yl)tridecan-2-yl) 2-formamido-4-methylpentanoate

Trade names Xenical, alli
AHFS/Drugs.com monograph
MedlinePlus a601244
Licence data EMA:Link, US FDA:link
Pregnancy
category
AU: B1
US: X (Contraindicated)
Legal status AU: S3 (Pharmacist only)
UK: Pharmacy medicines
US: OTC
Routes of
administration
Oral

Bioavailability Negligible[1]
Protein binding >99%
Metabolism In the GI tract
Biological half-life 1 to 2 hours
Excretion Fecal

CAS Number 96829-58-2
ATC code A08AB01
PubChem CID: 3034010
IUPHAR/BPS 5277
DrugBank DB01083
ChemSpider 2298564
UNII 95M8R751W8
KEGG D04028
ChEMBL CHEMBL175247

Formula C29H53NO5
Molecular mass 495.735 g/mol

SMILES[show]

InChI[show]