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aspartame

Aspartame

Aspartame (APM; /ˈæspərteɪm/ or /əˈspɑrteɪm/) is an artificial, non-saccharide sweetener used as a sugar substitute in some foods and beverages. In the European Union, it is codified as E951. Aspartame is a methyl ester of the aspartic acid/phenylalanine dipeptide. It was first sold under the brand name NutraSweet. It was first synthesized in 1965, and the patent expired in 1992.

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Product Description


IUPAC name

Methyl L-α-aspartyl-L-phenylalaninate
Other names

N-(L-α-Aspartyl)-L-phenylalanine,
1-methyl ester

CAS Number
22839-47-0
ChEBI CHEBI:2877
ChEMBL ChEMBL171679
ChemSpider 118630
DrugBank DB00168
Jmol interactive 3D Image
KEGG C11045
UNII Z0H242BBR1
InChI[show]
SMILES[show]

Chemical formula
C14H18N2O5
Molar mass 294.31 g·mol−1
Density 1.347 g/cm3
Melting point 246 to 247 °C (475 to 477 °F; 519 to 520 K)
Boiling point decomposes
Solubility in water
Sparingly soluble
Solubility Slightly soluble in ethanol
Acidity (pKa) 4.5–6.0[2]

NFPA 704