Aspartame (APM; /ˈæspərteɪm/ or /əˈspɑrteɪm/) is an artificial, non-saccharide sweetener used as a sugar substitute in some foods and beverages. In the European Union, it is codified as E951. Aspartame is a methyl ester of the aspartic acid/phenylalanine dipeptide. It was first sold under the brand name NutraSweet. It was first synthesized in 1965, and the patent expired in 1992.
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IUPAC name
Methyl L-α-aspartyl-L-phenylalaninate
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Other names
N-(L-α-Aspartyl)-L-phenylalanine,
1-methyl ester |
CAS Number
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22839-47-0 |
ChEBI | CHEBI:2877 |
ChEMBL | ChEMBL171679 |
ChemSpider | 118630 |
DrugBank | DB00168 |
Jmol interactive 3D | Image |
KEGG | C11045 |
UNII | Z0H242BBR1 |
InChI[show]
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SMILES[show]
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Chemical formula
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C14H18N2O5 |
Molar mass | 294.31 g·mol−1 |
Density | 1.347 g/cm3 |
Melting point | 246 to 247 °C (475 to 477 °F; 519 to 520 K) |
Boiling point | decomposes |
Solubility in water
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Sparingly soluble |
Solubility | Slightly soluble in ethanol |
Acidity (pKa) | 4.5–6.0[2] |
NFPA 704 |