Carbamazepine (CBZ), sold under the tradename Tegretol among others, is a medication used primarily in the treatment of epilepsy and neuropathic pain.[2] For seizures it works as well as phenytoin and valproate.[3][4] It is not effective for absence seizures or myoclonic seizures. It may be used in schizophrenia along with other medications and as a second line agent in bipolar disorder.[2] It is taken two to four times per day.[2] A controlled release formulation is available for which there is tentative evidence showing less side effects.[5]

Starting at
| 5H-dibenzo[b,f]azepine-5-carboxamide |
| Trade names | Tegretol |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a682237 |
| Licence data | US Daily Med:link |
| Pregnancy category |
AU: D US: D (Evidence of risk) |
| Legal status |
AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: ℞-only |
| Routes of administration |
Oral |
| Bioavailability | ~100%[1] |
| Protein binding | 70-80%[1] |
| Metabolism | Hepatic—by CYP3A4, to active epoxide form (carbamazepine-10,11 epoxide)[1] |
| Biological half-life | 36 hours (single dose), 16-24 hours (repeated dosing)[1] |
| Excretion | Urine (72%), feces (28%)[1] |
| CAS Number | 298-46-4 85756-57-6 |
| ATC code | N03AF01 |
| PubChem | CID: 2554 |
| IUPHAR/BPS | 5339 |
| DrugBank | DB00564 |
| ChemSpider | 2457 |
| UNII | 33CM23913M |
| KEGG | D00252 |
| ChEBI | CHEBI:3387 |
| ChEMBL | CHEMBL108 |
| Formula | C15H12N2O |
| Molecular mass | 236.269 g/mol |
| SMILES[show] | |
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InChI[show] |
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