Carbamazepine (CBZ), sold under the tradename Tegretol among others, is a medication used primarily in the treatment of epilepsy and neuropathic pain.[2] For seizures it works as well as phenytoin and valproate.[3][4] It is not effective for absence seizures or myoclonic seizures. It may be used in schizophrenia along with other medications and as a second line agent in bipolar disorder.[2] It is taken two to four times per day.[2] A controlled release formulation is available for which there is tentative evidence showing less side effects.[5]
Starting at
5H-dibenzo[b,f]azepine-5-carboxamide |
Trade names | Tegretol |
AHFS/Drugs.com | monograph |
MedlinePlus | a682237 |
Licence data | US Daily Med:link |
Pregnancy category |
AU: D US: D (Evidence of risk) |
Legal status |
AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: ℞-only |
Routes of administration |
Oral |
Bioavailability | ~100%[1] |
Protein binding | 70-80%[1] |
Metabolism | Hepatic—by CYP3A4, to active epoxide form (carbamazepine-10,11 epoxide)[1] |
Biological half-life | 36 hours (single dose), 16-24 hours (repeated dosing)[1] |
Excretion | Urine (72%), feces (28%)[1] |
CAS Number | 298-46-4 85756-57-6 |
ATC code | N03AF01 |
PubChem | CID: 2554 |
IUPHAR/BPS | 5339 |
DrugBank | DB00564 |
ChemSpider | 2457 |
UNII | 33CM23913M |
KEGG | D00252 |
ChEBI | CHEBI:3387 |
ChEMBL | CHEMBL108 |
Formula | C15H12N2O |
Molecular mass | 236.269 g/mol |
SMILES[show] | |
InChI[show] |