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chlorpheniramine-maleate

Chlorpheniramine Maleate

Chlorphenamine (INN), chlorpheniramine (USAN, former BAN) or piriton (trade name), commonly marketed in the form of chlorphenamine maleate (Chlorphen-12[1]), is a first-generation alkylamine antihistamine used in the prevention of the symptoms of allergic conditions such as rhinitis and urticaria. Its sedative effects are relatively weak compared to other first-generation antihistamines. Chlorphenamine is one of the most commonly used antihistamines in small-animal veterinary practice. Although not generally approved as an antidepressant or anti-anxiety medication, chlorphenamine appears to have these properties as well.[2][3]

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Product Description


3-(4-chlorophenyl)-N,N-dimethyl-
3-pyridin-2-yl-propan-1-amine

Trade names Chlor-trimeton
AHFS/Drugs.com monograph
MedlinePlus a682543
Pregnancy
category
AU: A
US: B (No risk in non-human studies)
Legal status AU: S3 (Pharmacist only)
UK: Pharmacy medicines
US: OTC
(for oral forms)
Routes of
administration
Oral, IV, IM, SC

Bioavailability 25 to 50%
Protein binding 72%
Metabolism Hepatic (CYP2D6)
Biological half-life 21–27 hours
Excretion Renal

CAS Number 113-92-8
ATC code R06AB04
PubChem CID: 2725
IUPHAR/BPS 1210
DrugBank DB01114
ChemSpider 2624
UNII 3U6IO1965U
KEGG D07398
ChEBI CHEBI:52010
ChEMBL CHEMBL505

Formula C16H19ClN2
Molecular mass 274.788 g/mol
SMILES[show]

InChI[show]

Solubility in water 0.55 g/100 mL, liquid mg/mL (20 °C)