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Vancomycin

Vancomycin is an antibiotic used to treat a number of bacterial infections. It is recommended intravenously as a first-line treatment for complicated skin infections, bloodstream infections, endocarditis, bone and joint infections, and meningitis caused by methicillin-resistant S. aureus. Blood levels may be measured to determine the correct dose. Vancomycin is also recommended by mouth as a treatment for severe Clostridium difficile colitis. When taken by mouth it is very poorly absorbed.

Common side effects include pain in the area of injection and allergic reactions. Occasionally problems with hearing, low blood pressure, or bone marrow suppression occur. Safety in pregnancy is not clear but there is no evidence of harm, and it is likely safe for use when breastfeeding. It is a type of the glycopeptide antibiotic and works by blocking the making of a cell wall.

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Product Description



(1S,2R,18R,19R,22S,25R,28R,40S)- 48- {[(2S,3R,4S,5S,6R)- 3- {[(2S,4S,5S,6S)- 4- amino- 5- hydroxy- 4,6- dimethyloxan- 2- yl]oxy}- 4,5- dihydroxy- 6- (hydroxymethyl)oxan- 2- yl]oxy}- 22- (carbamoylmethyl)- 5,15- dichloro- 2,18,32,35,37- pentahydroxy- 19- [(2R)- 4- methyl- 2- (methylamino)pentanamido]- 20,23,26,42,44- pentaoxo- 7,13- dioxa- 21,24,27,41,43- pentaazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta- 3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49- pentadecaene- 40- carboxylic acid


Pronunciation /væŋkɵˈmaɪsɨn/
Trade names Vancocin
AHFS/Drugs.com monograph
MedlinePlus a604038
Licence data US FDA:link
Pregnancy category
  • AU: B2
  • B (PO) / C (IV)(US)
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
Routes of administration IV, oral
Pharmacokinetic data
Bioavailability Negligible (oral)
Metabolism Excreted unchanged
Biological half-life 4–11 hours (adults) 6-10 days (adults, impaired renal function)
Excretion Renal


Bioavailability Negligible (oral)
Metabolism Excreted unchanged
Biological half-life 4–11 hours (adults)
6-10 days (adults, impaired renal function)
Excretion Renal


CAS Number 1404-90-6
ATC code A07AA09 J01XA01
PubChem CID: 14969
DrugBank DB00512
ChemSpider 14253
UNII 6Q205EH1VU
KEGG D00212
ChEBI CHEBI:28001
ChEMBL CHEMBL262777


Formula C66H75Cl2N9O24
Molecular mass 1449.3 g.mol−1

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