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Dexamethasone_structure

Dexamethasone Phosphate

Dexamethasone is a type of steroid medication.[1] It is used in the treatment of rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive lung disease, croup, brain swelling, and along with antibiotics in tuberculosis, among others.[1] In adrenocortical insufficiency it should be used together with a medication that has greater mineralocorticoid effects such as fludrocortisone.[1] In preterm labor it may be used to improve outcomes in the baby.[1] It may be taken by mouth, as an injection into a muscle, or intravenously.[1] The effects of dexamethasone are frequently seen within a day and last for about three days.[1]

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Product Description


(8S,9R,10S,11S,13S,14S,16R,17R)-9- Fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17- dodecahydro-3H-cyclopenta[a]phenanthren-3-one

AHFS/Drugs.com monograph
MedlinePlus a682792
Pregnancy
category
AU: A
US: C (Risk not ruled out)
Legal status AU : S4 (Prescription only)
CA : ℞-only
UK POM (Prescription only)
US : ℞-only
Routes of
administration
Oral, IV, IM, SC and IO

Bioavailability 80-90%
Protein binding 77%
Metabolism hepatic
Biological half-life 190 minutes
Excretion Urine (65%)

CAS Number 50-02-2
ATC code A01AC02 C05AA09, D07AB19, D10AA03, H02AB02, R01AD03, S01BA01,S02BA06, S03BA01
PubChem CID: 5743
IUPHAR/BPS 2768
DrugBank DB01234
ChemSpider 5541
UNII 7S5I7G3JQL
KEGG D00292
ChEBI CHEBI:41879
ChEMBL CHEMBL384467

Formula C22H29FO5
Molecular mass 392.461 g/mol
SMILES[show]
InChI[show]

Melting point 262 °C (504 °F)