Dexamethasone is a type of steroid medication.[1] It is used in the treatment of rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive lung disease, croup, brain swelling, and along with antibiotics in tuberculosis, among others.[1] In adrenocortical insufficiency it should be used together with a medication that has greater mineralocorticoid effects such as fludrocortisone.[1] In preterm labor it may be used to improve outcomes in the baby.[1] It may be taken by mouth, as an injection into a muscle, or intravenously.[1] The effects of dexamethasone are frequently seen within a day and last for about three days.[1]
Starting at
(8S,9R,10S,11S,13S,14S,16R,17R)-9- Fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17- dodecahydro-3H-cyclopenta[a]phenanthren-3-one
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AHFS/Drugs.com | monograph |
MedlinePlus | a682792 |
Pregnancy category |
AU: A US: C (Risk not ruled out) |
Legal status |
AU : S4 (Prescription only) CA : ℞-only UK POM (Prescription only) US : ℞-only |
Routes of administration |
Oral, IV, IM, SC and IO |
Bioavailability | 80-90% |
Protein binding | 77% |
Metabolism | hepatic |
Biological half-life | 190 minutes |
---|---|
Excretion | Urine (65%) |
CAS Number | 50-02-2 |
ATC code | A01AC02 C05AA09, D07AB19, D10AA03, H02AB02, R01AD03, S01BA01,S02BA06, S03BA01 |
PubChem | CID: 5743 |
IUPHAR/BPS | 2768 |
DrugBank | DB01234 |
ChemSpider | 5541 |
UNII | 7S5I7G3JQL |
KEGG | D00292 |
ChEBI | CHEBI:41879 |
ChEMBL | CHEMBL384467 |
Formula | C22H29FO5 |
Molecular mass | 392.461 g/mol |
SMILES[show] | |
InChI[show] |
Melting point | 262 °C (504 °F) |