Gentamicin, sold under brand names Garamycin among others, is an antibiotic used to treat many types of bacterial infections.[1] This may include bone infections, endocarditis, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, and sepsis among others. It is not effective for gonorrhea or chlamydia infections. It can be given intravenously, by injection into a muscle, or topically.[1] Topical formulations may be used in burns or for infections of the outside of the eye.[2] In the developed world it is often only used for two days until bacterial cultures determine what antibiotics the infection is sensitive to.[3] The dose required should be monitored by blood testing.[1]
Starting at
(3R,4R,5R)-2-{[(1S,2S,3R,4S,6R)-4,6- diamino-3-{[(2R,3R,6S)- 3-amino-6-[(1R)- 1-(methylamino)ethyl]oxan-2-yl]oxy}- 2-hydroxycyclohexyl]oxy}-5-methyl- 4-(methylamino)oxane-3,5-diol |
Trade names | Cidomycin, Septopal, Genticyn, Garamycin, others |
AHFS/Drugs.com | monograph |
MedlinePlus | a682275 |
Pregnancy category |
D |
Legal status | UK: POM (Prescription only) |
Routes of administration |
IV, eye drop, IM, topical |
Bioavailability | limited oral bioavailability |
Protein binding | 0-10% |
Biological half-life | 2 hrs |
Excretion | renal |
CAS Number | 1403-66-3 |
ATC code | D06AX07 J01GB03 S01AA11 S02AA14 S03AA06 QA07AA91 QG01AA91 QG51AA04 QJ51GB03 |
PubChem | CID: 3467 |
IUPHAR/BPS | 2427 |
DrugBank | DB00798 |
ChemSpider | 390067 |
UNII | T6Z9V48IKG |
KEGG | D08013 |
ChEBI | CHEBI:27412 |
ChEMBL | CHEMBL195892 |
Formula | C21H43N5O7 |
Molecular mass | 477.596 g/mol |
SMILES[show] | |
InChI[show] |