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gentamicin-sulfate

Gentamicin Sulfate

Gentamicin, sold under brand names Garamycin among others, is an antibiotic used to treat many types of bacterial infections.[1] This may include bone infections, endocarditis, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, and sepsis among others. It is not effective for gonorrhea or chlamydia infections. It can be given intravenously, by injection into a muscle, or topically.[1] Topical formulations may be used in burns or for infections of the outside of the eye.[2] In the developed world it is often only used for two days until bacterial cultures determine what antibiotics the infection is sensitive to.[3] The dose required should be monitored by blood testing.[1]

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Product Description


(3R,4R,5R)-2-{[(1S,2S,3R,4S,6R)-4,6-
diamino-3-{[(2R,3R,6S)-
3-amino-6-[(1R)-
1-(methylamino)ethyl]oxan-2-yl]oxy}-
2-hydroxycyclohexyl]oxy}-5-methyl-
4-(methylamino)oxane-3,5-diol

Trade names Cidomycin, Septopal, Genticyn, Garamycin, others
AHFS/Drugs.com monograph
MedlinePlus a682275
Pregnancy
category

D

Legal status UK: POM (Prescription only)

Routes of
administration
IV, eye drop, IM, topical

Bioavailability limited oral bioavailability
Protein binding 0-10%
Biological half-life 2 hrs
Excretion renal

CAS Number 1403-66-3
ATC code D06AX07 J01GB03 S01AA11 S02AA14 S03AA06 QA07AA91 QG01AA91 QG51AA04 QJ51GB03
PubChem CID: 3467
IUPHAR/BPS 2427
DrugBank DB00798
ChemSpider 390067
UNII T6Z9V48IKG
KEGG D08013
ChEBI CHEBI:27412
ChEMBL CHEMBL195892

Formula C21H43N5O7
Molecular mass 477.596 g/mol
SMILES[show]
InChI[show]