Guaifenesin INN /ɡwaɪˈfɛnᵻsɪn/ or guaiphenesin (former BAN), also glyceryl guaiacolate,[2] is an expectorant drug sold over the counter and usually taken orally to assist the bringing up (expectoration) of phlegm from the airways in acute respiratory tract infections.

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(RS)-3-(2-methoxyphenoxy)propane-1,2-diol
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| Trade names | Mucinex |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a682494 |
| Licence data | US FDA:link |
| Pregnancy category |
US: C (Risk not ruled out) |
| Legal status | US: OTC |
| Routes of administration |
Oral |
| Metabolism | Renal |
| Biological half-life | 1-5 hours[1] |
| CAS Number | 93-14-1 |
| ATC code | R05CA03 QM03BX90 |
| PubChem | CID: 3516 |
| IUPHAR/BPS | 7617 |
| DrugBank | DB00874 |
| ChemSpider | 3396 |
| UNII | 495W7451VQ |
| KEGG | D00337 |
| ChEMBL | CHEMBL980 |