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Ketoconazole

Ketoconazole

Ketoconazole (/ˌkiːtoʊˈkoʊnəˌzoʊl, -zɒl/[1][2]) (INN, USAN, BAN, JAN) is a synthetic imidazole antifungal drug used primarily to treat fungal infections. Ketoconazole is sold commercially as a tablet for oral administration (although this use has been discontinued in a number of countries), and in a variety of formulations for topical administration, such as creams (used to treat tinea; cutaneous candidiasis, including candidal paronychia; and pityriasis versicolor) and shampoos (used primarily to treat dandruff—seborrhoeic dermatitis of the scalp).[3]

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Product Description


1-[4-(4-{[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one

Trade names Nizoral
AHFS/Drugs.com monograph
MedlinePlus a682816
Licence data US FDA:link
Pregnancy
category
AU : B3
US : C (Risk not ruled out)
Legal status UK: POM (Prescription only)
US: OTC
Routes of
administration
Oral, topical

Bioavailability Variable
Protein binding 84 to 99%
Metabolism Hepatic
Biological half-life Biphasic
Excretion Biliary and renal

CAS Number 65277-42-1
ATC code J02AB02 D01AC08 G01AF11
PubChem CID: 456201
IUPHAR/BPS 2568
DrugBank DB01026
ChemSpider 401695
UNII R9400W927I
KEGG D00351
ChEBI CHEBI:48336
ChEMBL CHEMBL75
PDB ligand ID KTN (PDBe, RCSB PDB)

Formula C26H28Cl2N4O4
Molecular mass 531.431 g/mol
SMILES[show]
>InChI[show]