Loperamide
Loperamide, sold under the brand name Imodium among others,[1] is a medication used to decrease the frequency of diarrhea.[2] It is often used for this purpose in gastroenteritis, inflammatory bowel disease, and short bowel syndrome. It is not recommended for those with blood in the stool. The medication is taken by mouth.[2]
Starting at
Product Description
|
4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
|
| Pronunciation | /loʊˈpɛrəmaɪd/ |
| Trade names | Imodium, others[1] |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a682280 |
| Pregnancy category |
AU: B3 US: C (Risk not ruled out) |
| Legal status |
AU: S2 (Pharmacy only) CA: OTC UK: General sales list (GSL, OTC) US: OTC |
| Routes of administration |
Oral |
| Bioavailability | 0.3% |
| Protein binding | 97% |
| Metabolism | Liver (extensive) |
| Biological half-life | 9-14 hours[2] |
| Excretion | Faeces (30-40%), urine (1%) |
| CAS Number | 53179-11-6 34552-83-5 (with HCl) |
| ATC code | A07DA03 A07DA05 (oxide) |
| PubChem | CID: 3955 |
| IUPHAR/BPS | 7215 |
| DrugBank | DB00836 |
| ChemSpider | 3818 |
| UNII | 6X9OC3H4II |
| KEGG | D08144 |
| ChEBI | CHEBI:6532 |
| ChEMBL | CHEMBL841 |
| Synonyms | R-18553 |
