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triclabendazole-product

Triclabendazole

Triclabendazole (commercial names: veterinary, liquid: Fasinex ; human, tablets: Egaten , both manufactured by Novartis) is a member of the benzimidazole family of anthelmintics. The benzimidazole drugs share a common molecular structure, triclabendazole being the exception in having a chlorinated benzene ring but no carbamate group. Benzimidazoles such as triclabendazole are generally accepted to bind to beta-tubulin and prevent the polymerization of the microtubules of which they are part.

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Product Description



Systematic (IUPAC) name
5-Chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole


Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy category ?

Legal status

?

Routes of administration ?


Pharmacokinetic data
Metabolism oxidation to the sulfone and sulfoxide parent compound
Biological half-life 22 – 24 hs
Excretion >95% in faeces, 2% in urine, and < 1% in milk


Identifiers
CAS Number 68786-66-3
ATC code P02BX04 QP52AC01
PubChem CID: 50248
ChemSpider 45565
UNII 4784C8E03O
ChEMBL CHEMBL1086440


Chemical data
Formula C14H9Cl3N2OS
Molecular mass 359.658

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