Cyproheptadine (/ˌsaɪproʊˈhɛptədiːn/[4][5]), sold under the brand name Periactin or Peritol, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties.
Starting at
4-(5H-dibenzo [a,d]cyclohepten-5-ylidene)-1-methylpiperidine hydrochloride |
Trade names | Periactin |
AHFS/Drugs.com | monograph |
MedlinePlus | a682541 |
Licence data | US Daily Med:link |
Pregnancy category |
AU: A US: B (No risk in non-human studies) |
Legal status |
AU: S3 (Pharmacist only) CA: OTC UK: OTC |
Routes of administration |
Oral |
Protein binding | 96 to 99% |
Metabolism | Hepatic[1][2] |
Biological half-life | 8.6 hours[3] |
Excretion | Faecal (2-20%; 34% of this as unchanged drug) and renal (40%; none as unchanged drug)[1][2] |
CAS Number | 129-03-3 969-33-5 (hydrochloride) |
ATC code | R06AX02 |
PubChem | CID: 2913 |
IUPHAR/BPS | 277 |
DrugBank | DB00434 |
ChemSpider | 2810 |
UNII | 2YHB6175DO |
KEGG | D07765 |
ChEBI | CHEBI:4046 |
ChEMBL | CHEMBL516 |
Formula | C21H21N |
Molecular mass | 287.398 g/mol |
SMILES[show] | |
InChI[show] |
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