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carbamazepine-Micronized

Carbamazepine (Micronized)

Carbamazepine (CBZ), sold under the tradename Tegretol among others, is a medication used primarily in the treatment of epilepsy and neuropathic pain.[2] For seizures it works as well as phenytoin and valproate.[3][4] It is not effective for absence seizures or myoclonic seizures. It may be used in schizophrenia along with other medications and as a second line agent in bipolar disorder.[2] It is taken two to four times per day.[2] A controlled release formulation is available for which there is tentative evidence showing less side effects.[5]

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Product Description


5H-dibenzo[b,f]azepine-5-carboxamide

Trade names Tegretol
AHFS/Drugs.com monograph
MedlinePlus a682237
Licence data US Daily Med:link
Pregnancy
category
AU: D
US: D (Evidence of risk)
Legal status AU: S4 (Prescription only)
CA: ℞-only
UK: POM (Prescription only)
US: ℞-only
Routes of
administration
Oral

Bioavailability ~100%[1]
Protein binding 70-80%[1]
Metabolism Hepatic—by CYP3A4, to active epoxide form (carbamazepine-10,11 epoxide)[1]
Biological half-life 36 hours (single dose), 16-24 hours (repeated dosing)[1]
Excretion Urine (72%), feces (28%)[1]

CAS Number 298-46-4 85756-57-6
ATC code N03AF01
PubChem CID: 2554
IUPHAR/BPS 5339
DrugBank DB00564
ChemSpider 2457
UNII 33CM23913M
KEGG D00252
ChEBI CHEBI:3387
ChEMBL CHEMBL108

Formula C15H12N2O
Molecular mass 236.269 g/mol
SMILES[show]

InChI[show]