Aspartic acid (abbreviated as Asp or D; encoded by the codons [GAU and GAC]) is an ɑ-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated -+NH3 form under biological conditions), an α-carboxylic acid group (which is in the deprotonated –COO- form under biological conditions), and a side chain CH2COOH, classifying it as a charged(at physiological pH), aliphatic amino acid. It is semi-essential in humans, meaning the body can synthesize it from oxaloacetate.
Asp's L-isomer is one of the 23 proteinogenic amino acids, i.e., the building blocks of proteins. Asp (and glutamic acid) is classified as acidic, with a pKa of 3.9, however in a peptide this is highly dependent on the local environment (as with all amino acids), and could be as high as 14. Asp is pervasive in biosynthesis.
Starting at $13.23
IUPAC names
Trivial: Aspartic acid Systematic: 2-Aminobutanedioic acid
|
|
Other names
Aminosuccinic acid, asparagic acid, asparaginic acid[1]
|
CAS Number
|
617-45-8 56-84-8 (L-isomer) 1783-96-6 (D-isomer) |
ChEBI | CHEBI:22660 |
ChEMBL | ChEMBL139661 |
ChemSpider | 411 |
EC Number | 200-291-6 |
Jmol interactive 3D | |
KEGG | C16433 |
PubChem | 424 |
UNII | 28XF4669EP |
InChI[show]
|
|
SMILES[show]
|
Chemical formula
|
C4H7NO4 |
Molar mass | 133.10 ;g·mol−1 |
Appearance | colourless crystals |
Density | 1.7 g/cm3 |
Melting point | 270 ;°C (518 ;°F; 543 ;K) |
Boiling point | 324 ;°C (615 ;°F; 597 ;K) (decomposes) |
Solubility in water
|
4.5 g/L[2] |
Acidity (pKa) | 3.9 |
Safety data sheet | See: data page |
NFPA 704 |
|
Structure and properties
|
Refractive index (n), Dielectric constant (εr), etc. |
Thermodynamic data
|
Phase behaviour solid–liquid–gas |
Spectral data
|
UV, IR, NMR, MS |
kg | 500 grams, 1 kilo, 5 kilo, 10 kilo, 25 kilo |
---|