Glutamic acid (abbreviated as Glu or E ; encoded by the codons GAA or GAG) is an ɑ-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated -+NH3 form under biological conditions), an α-carboxylic acid group (which is in the deprotonated –COO- form under biological conditions), and a side chain carboxylic acid, classifying it as a polar negatively charged (at physiological pH), aliphatic amino acid. It is non-essential in humans, meaning the body can synthesize it.
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Systematic IUPAC name
2-Aminopentanedioic acid
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Other names
2-Aminoglutaric acid
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CAS Number
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56-86-0 (L isomer) 617-65-2 (D/L racemate) |
ChEBI | CHEBI:18237 |
ChEMBL | ChEMBL276389. |
ChemSpider | 591 |
Jmol interactive 3D | Image |
KEGG | D0434 |
UNII | 61LJO5I15S |
InChI[show]
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SMILES[show]
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Chemical formula
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C5H9NO4 |
Molar mass | 147.13 g·mol−1 |
Appearance | white crystalline powder |
Density | 1.4601 (20 °C) |
Melting point | 199 °C (390 °F; 472 K) decomposes |
Solubility in water
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7.5 g/L (20 °C)[1] |
Solubility | 0.00035g/100g ethanol (25 °C)[2] |
Acidity (pKa) | 2.1, 4.07, 9.47 [3] |
Safety data sheet | See: data page |
NFPA 704 |
Structure and
properties |
Refractive index (n), Dielectric constant (εr), etc. |
Thermodynamic
data |
Phase behaviour solid–liquid–gas |
Spectral data
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UV, IR, NMR, MS |