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cinarizina

CINARIZINA

Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker,[1] it is also known to promote cerebral blood flow, and so is used to treat cerebral apoplexy, post-trauma cerebral symptoms, and cerebral arteriosclerosis.[2] However, it is more commonly prescribed for nausea and vomiting due to motion sickness [3] or other sources such as chemotherapy,[4] vertigo,[5] or Ménière's disease.[6] Cinnarizine was first synthesized by Janssen Pharmaceutica in 1955. The nonproprietary name is derived from the cinnamyl substituent on one of the nitrogen atoms, combined with the generic ending “-rizine” for “antihistaminics/cerebral (or peripheral) vasodilators”.[7] It is not available in the United States or Canada. It is manufactured and marketed in Bangladesh under the trade name Suzaraon by Rephco Pharmaceuticals Limited. It has also been cited as one of the most used drugs for seasickness within the British Royal Navy.[8]

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Product Description


(E)-1-(Diphenylmethyl)-4-(3-phenylprop-2-enyl)piperazine

Trade names Stugeron, Stunarone, Arlevert, Diznil-25
AHFS/Drugs.com International Drug Names
Pregnancy
category
US: C (Risk not ruled out)
Legal status UK: Pharmacy medicines
Routes of
administration
Oral

Biological half-life 3–4 h

CAS Number 298-57-7
ATC code N07CA02
PubChem CID: 1547484
DrugBank DB00568
ChemSpider 1264793
UNII 3DI2E1X18L
KEGG D01295
ChEBI CHEBI:31403
ChEMBL CHEMBL43064

Formula C26H28N2
Molecular mass 368.514 g/mol

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InChI[show]

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