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clorxozazona

CLORXOZAZONA

Chlorzoxazone (INN) is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes. It is sold under the trade names Paraflex and Muscol and in combination form as Parafon Forte, a combination of chlorzoxazone and acetaminophen (paracetamol). Possible side effects include dizziness, lightheadedness, malaise, nausea, vomiting, and liver dysfunction. Used with acetaminophen it has added risk of hepatoxicity,[medical citation needed] which is why the combination is not recommended. It can also be administered for acute pain in general and for tension headache (muscle contraction headache).

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Product Description


5-chloro-3H-benzooxazol-2-one

Trade names Parafonforte
AHFS/Drugs.com monograph
MedlinePlus a682577
Routes of
administration
oral

Bioavailability well absorbed
Protein binding 13–18%
Metabolism hepatic
Biological half-life 1.1 hr
Excretion urine (<1%)

CAS Number 95-25-0
ATC code M03BB03
PubChem CID: 2733
IUPHAR/BPS 2322
DrugBank DB00356
ChemSpider 2632
UNII H0DE420U8G
KEGG D00771
ChEBI CHEBI:3655
ChEMBL CHEMBL1371

Formula C7H4ClNO2
Molecular mass 169.565 g/mol
SMILES[show]
InChI[show]

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