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diphenidol-hcl

DIFENIDOL HCL

Diphenidol is a muscarinic antagonist employed as an antiemetic and as an antivertigo agent. It is not marketed in the United States or Canada. – Although the mechanism of action of Diphenidol on the vestibular system has not yet been elucidated, it exerts an anticholinergic effect due to interactions with mACh receptors, particularly M1, M2, M3 and M4. Hence, its actions may take place at the vestibular nuclei, where a significant excitatory input is mediated by ACh receptors, and also at the vestibular periphery where mACh receptors are expressed at efferent synapses. Recently, a series of selective mACh-receptor antagonists based on the Diphenidol molecule has been synthesized, but they have not yet been the subject of clinical trials* .

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Product Description


1,1-di(phenyl)-4-piperidin-1-ylbutan-1-ol

AHFS/Drugs.com Micromedex Detailed Consumer Information
Routes of
administration
Oral

Biological half-life 4 hours

CAS Number 972-02-1
ATC code None
PubChem CID: 9175
IUPHAR/BPS 7163
DrugBank DB01231
ChemSpider 2947
UNII NQO8R319LY
KEGG D03858
ChEBI CHEBI:4638
ChEMBL CHEMBL936

Formula C21H27NO
Molecular mass 309.44518 g/mol
SMILES[show]
InChI[show]

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