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Metamizole

DIPIRONA DE MAGNESIO

Metamizole (INN), or dipyrone (BAN, USAN), is an ampyrone sulfonate analgesic (pain reliever), antispasmodic (spasm reliever) and antipyretic (fever reducer) similar to paracetamol in that it has minimal anti-inflammatory effects and which is most commonly given orally or parenterally (by injection) to prevent and treat pain related to surgery or for the treatment of acute pain.[2][5] It was first introduced into clinical use in Germany in 1922 under the brandname “Novalgin” and for many years it was available over-the-counter in most countries, until its toxicities became apparent,[6] although in some countries it is available over-the-counter, its use is usually restricted in developed countries, due to its potential for causing toxic reactions.[7]

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Product Description


[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino] methanesulfonic acid

Trade names Originally Novalgin,[3] now generic[4]
AHFS/Drugs.com International Drug Names
Pregnancy
category
None assigned; no evidence of teratogenicity in animal studies, but use in the third trimester may cause adverse effects in the newborn or ductus arteriosus (a heart defect) due to its weak NSAID activity.[1][2]
Legal status Over-the-counter (some countries, see text); prescription-only (others); withdrawn (others)
Routes of
administration
Oral, IM, IV, rectal

Bioavailability 100% (active metabolites)[5]
Protein binding 48%-58% (active metabolites)[5]
Metabolism Liver[5]
Biological half-life 14 minutes (parent compound; parenteral);[2] metabolites: 2–4 hours[5]
Excretion Urine (96%, IV; 85%, oral), faeces (4%, IV).[2]

CAS Number 68-89-3 (sodium salt)
ATC code N02BB02
PubChem CID: 80254
DrugBank DB04817
ChemSpider 3000
UNII VSU62Z74ON
ChEBI CHEBI:59033
ChEMBL CHEMBL487894

Formula C13H17N3O4S
Molecular mass 311.357 g/mol
SMILES[show]
InChI[show]

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