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TIANFENICOL BP 2000

Thiamphenicol (also known as thiophenicol and dextrosulphenidol) is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, it is insoluble in water, but highly soluble in lipids. It is used in many countries as a veterinary antibiotic, but is available in China, Morocco and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.

Thiamphenicol is also widely used in Brazil, particularly for the treatment of sexually transmitted infections and pelvic inflammatory disease.

Unlike chloramphenicol, thiamphenicol is not readily metabolized in cattle, poultry, sheep, or humans, but is predominantly excreted unchanged. In pigs and rats the drug is excreted both as parent drug and as thiamphenicol glucuronate (FAO, 1997).

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Product Description



2,2-dichloro-N-{(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl}acetamide


AHFS/Drugs.com International Drug Names
Pregnancy
category
  •  ?
Legal status
  • none
Routes of
administration
IV, IM, oral


Bioavailability ?
Metabolism hepatic
Biological half-life 5.0 hours
Excretion renal


CAS Number 15318-45-3 
ATC code J01BA02 QJ51BA02
PubChem CID: 27200
DrugBank DB08621 
ChemSpider 25315 
UNII FLQ7571NPM 
KEGG D01407 
ChEBI CHEBI:32215 
ChEMBL CHEMBL1236282 


Formula C12H15Cl2NO5S
Molecular mass 356.223 g/mol

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