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Valproic_acid

VALPROATO DE MAGNESIO

Valproate (VPA), also known valproic acid, sodium valproate, and divalproex sodium, is a medication primarily used to treat epilepsy and bipolar disorder and to prevent migraine headaches.[2] It is useful for the prevention of seizures in those with absence seizures, partial seizures, and generalized seizures. It can be given intravenously or by mouth. Long acting formulations exist.[2]

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Product Description


2-propylpentanoic acid

Trade names Convulex, Depakote, Epilim, Stavzor, Vilapro
AHFS/Drugs.com monograph
MedlinePlus a682412
Licence data US FDA:link
Pregnancy
category
AU : D
US : X (Contraindicated) – for control of conditions other than severe epilepsy not amenable to other drugs
Legal status AU : S4 (Prescription only)
CA : ℞-only
UK : POM (Prescription only)
US : ℞-only
Routes of
administration
Oral, intravenous

Bioavailability Rapid absorption
Protein binding 80-90%[1]
Metabolism Hepatic—glucuronide conjugation 30–50%, mitochondrial β-oxidation over 40%
Biological half-life 9–16 hours[1]
Excretion Urine (30-50%)[1]

CAS Number 99-66-1
ATC code N03AG01
PubChem CID: 3121
DrugBank DB00313
ChemSpider 3009
UNII 614OI1Z5WI
KEGG D00399
ChEBI CHEBI:39867
ChEMBL CHEMBL109
NIAID ChemDB 057177
Synonyms 2-Propylvaleric acid

Chemical data
Formula C8H16O2
Molecular mass 144.211 g/mol
SMILES[show]
InChI[show]

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